2-Amino-5-bromopyridine → HCID 19072852, compound

HRID 1856463Notes

Reaction equation

HRID 1856463 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([N:6]=[C:7]=[O:8])=[O:5].[Br:14][C:15]1[CH:16]=[CH:17][C:18]([NH2:21])=[N:19][CH:20]=1>C(OCC)(=O)C>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:3]=1[C:4]([NH:6][C:7]([NH:21][C:18]1[CH:17]=[CH:16][C:15]([Br:14])=[CH:20][N:19]=1)=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 129127392,6-Dichlorobenzoyl isocyanate

Product 1

HCID 19072852HCID 19072852, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,6-Dichlorobenzoyl isocyanate (2.16 grams; 0.01 mole) and 5-bromo-2-aminopyridine (1.73 grams; 0.01 mole) were mixed in 50 ml. of ethyl acetate, at room temperature. The reaction mixture was stirred at room temperature for 4 hours, during which the product precipitated. It was separated by filtration and recrystallized from ethanol, m.p. 228°-230° C., yield 2.0 grams. Elemental analysis showed:

Workup

  1. customat room temperature
  2. customprecipitated
  3. customIt was separated by filtration
  4. customrecrystallized from ethanol, m.p. 228°-230° C., yield 2.0 grams

Sources & evidence

ORD record
ord-10ac0059256a47e4b952c52e907ccbe0
Source dataset
uspto-grants-1980_08
Patent number
US04219557

Reaction notes

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