Sodium Chloride → HCID 9950286, compound

HRID 1856720Notes

Reaction equation

HRID 1856720 reaction equation
[CH2:1]([NH:8][C:9]1[N:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[NH:15][CH:14]=[C:13]([C:19]([OH:21])=O)[C:12]2=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.ClC(OCC)=O.[CH2:36]([NH2:40])[CH2:37][CH2:38][CH3:39].[Cl-].[Na+]>CN(C)C=O>[CH2:36]([NH:40][C:19]([C:13]1[C:12](=[O:22])[C:11]2[C:16](=[CH:17][CH:18]=[C:9]([NH:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[N:10]=2)[NH:15][CH:14]=1)=[O:21])[CH2:37][CH2:38][CH3:39]

Participants

7

Reactant 5

HCID 5234Sodium ChlorideHCID 8007ButylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 18000177HCID 18000177, compound

Product 1

HCID 9950286HCID 9950286, compoundYield 69.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 6-benzylamino-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid (59 mg, 0.2 mmol) and triethylamine (59 ml, 0.42 mmol) in N,N-dimethylformamide (1 mL) at 0° C. was added ethyl chloroformate (39 mL, 0.41 mmol). After stirring at 0° C. for 1 h, n-butylamine 99 mL, 1.0 mmol) was added. The reaction mixture was stirred an additional 2 h at 0° C., then poured into saturated aqueous sodium chloride. The mixture was cooled in an ice bath, the precipitate collected, rinsed with water and ether, then dried to afford 49 mg of N-n-butyl 6-benzylamino-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxamide as a brown solid. Compound 1. An alternate name for this compound is: N-butyl(4-oxo-6-(benzylamino)(3-hydro-5-azaquinolyl))formamide.

Workup

  1. stirringThe reaction mixture was stirred an additional 2 h at 0° C.
  2. temperatureThe mixture was cooled in an ice bath
  3. customthe precipitate collected
  4. washrinsed with water and ether
  5. customdried

Sources & evidence

ORD record
ord-e214059f375b4fcfa8bd1ed730d2659c
Source dataset
uspto-grants-2000_11
Patent number
US06143760

Reaction notes

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