反应详情

温度

75 °C

A suspension of 6-hydroxycarbostyril (300 g) and potassium carbonate (308 g) in dimethylformamide (2 liters) is heated with stirring at 70-80° C. for one hour. To the suspension is added N-(3-bromopropyl)phthalimide (498 g), and the mixture is further stirred at the same temperature for 9 hours. The reaction solution is poured into ice-water, and the precipitated crystals are collected by filtration, washed successively with water, ethanol and diethyl ether, and dried to give 6-(3-phthalimidopropoxy)carbostyril (410 g) as a white powder.

1. temperatureis heated
2. stirringthe mixture is further stirred at the same temperature for 9 hours
3. filtrationthe precipitated crystals are collected by filtration
4. washwashed successively with water, ethanol and diethyl ether
5. customdried