1,2-Epoxybutane → HCID 419885, compound

HRID 1856753Notes

Reaction equation

HRID 1856753 reaction equation
[O:1]1[CH:3]([CH2:4][CH3:5])[CH2:2]1.[CH:6]1([NH2:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>CO>[OH:1][CH:3]([CH2:4][CH3:5])[CH2:2][NH:12][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 78341,2-EpoxybutaneHCID 7965Cyclohexylamine

Product 1

HCID 419885HCID 419885, compoundYield 61.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To methanol (200 ml) are added 1,2-epoxybutane (72.2 g) and cyclohexylamine (99.2 g), and the mixture is refluxed for 6 hours. The mixture is concentrated under reduced pressure to remove the solvent to give N-(2-hydroxybutyl)-N-cyclohexylamine (105 g) as a colorless oil.

Workup

  1. temperaturethe mixture is refluxed for 6 hours
  2. concentrationThe mixture is concentrated under reduced pressure
  3. customto remove the solvent

Sources & evidence

ORD record
ord-38355a80b6c242448ed373ecf5e8779b
Source dataset
uspto-grants-2000_11
Patent number
US06143763

Reaction notes

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