反应详情

A solution of 2.0 g (8.7 mmol) of 5-amino-2-(3,3,3-trifluoropropyl) benzofuran in 30 ml of a 9/1 mixture of tetrahydrofuran and water is reacted for 30 min with 0.92 ml (9.6 mmol) of ethyl chloroformate in the presence of 1.1 g (13 mmol) of sodium hydrogen-carbonate. The reaction mixture is then diluted with water and dichloromethane, and then the organic phase is separated, dried over sodium sulfate and concentrated under reduced pressure. 2.5 g of product are obtained. Melting point: 108° C.

1. customthe organic phase is separated
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated under reduced pressure