2-Naphthol → HCID 15479026, compound

HRID 1857098Notes

Reaction equation

HRID 1857098 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][C:17]=1[OH:26]>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:26][C:17]1[CH:18]=[CH:19][C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:16]=1

Participants

3

Reactant 2

HCID 86632-NaphtholHCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 15479026HCID 15479026, compoundYield 68%

Conditions

Temperature
180 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (45 mg) and commercially available β-naphthol (144 mg) were mixed and stirred at 180° C. for 2 hours, and the reaction mixture was then purified in the same manner as described in Example 2 to obtain 45 mg of the title compound (yield: 68%).

Workup

  1. customthe reaction mixture was then purified in the same manner

Sources & evidence

ORD record
ord-25b01e331ca0437eb7d1f04bdb779b6c
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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