4-Chloro-6,7-dimethoxyquinoline → 6,7-Dimethoxy-4-(7-methoxy-2-naphthyloxy)quinoline

HRID 1857099Notes

Reaction equation

HRID 1857099 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH3:16][O:17][C:18]1[CH:27]=[C:26]2[C:21]([CH:22]=[CH:23][C:24]([OH:28])=[CH:25]2)=[CH:20][CH:19]=1>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:28][C:24]1[CH:23]=[CH:22][C:21]2[C:26](=[CH:27][C:18]([O:17][CH3:16])=[CH:19][CH:20]=2)[CH:25]=1

Participants

3

Reactant 2

HCID 4596104-Chloro-6,7-dimethoxyquinolineHCID 8531737-Methoxy-2-naphthol

Product 1

HCID 154790276,7-Dimethoxy-4-(7-methoxy-2-naphthyloxy)quinolineYield 41%

Conditions

Temperature
180 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (89 mg) and commercially available 7-methoxy-2-naphthol (209 mg) were mixed and stirred at 180° C. for 30 minutes, and the reaction mixture was then purified in the same manner as described in Example 2 to obtain 59 mg of the title compound (yield: 41%).

Workup

  1. customthe reaction mixture was then purified in the same manner

Sources & evidence

ORD record
ord-00d3728ce7a9451f89a38a67fd578b5f
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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