3,4-Dimethoxyphenol → HCID 9927943, compound

HRID 1857102Notes

Reaction equation

HRID 1857102 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([OH:26])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:26][C:20]1[CH:21]=[CH:22][C:23]([O:24][CH3:25])=[C:18]([O:17][CH3:16])[CH:19]=1

Participants

3

Reactant 2

HCID 162513,4-DimethoxyphenolHCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 9927943HCID 9927943, compoundYield 19%

Conditions

Temperature
180 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (90 mg) and commercially available 3,4-dimethoxyphenol (187 mg) were mixed and stirred at 180° C. for 30 minutes, and the mixture was then purified by column chromatography on silica gel eluting with hexane/acetone to obtain 26 mg of the title compound (yield: 19%).

Workup

  1. customthe mixture was then purified by column chromatography on silica gel eluting with hexane/acetone

Sources & evidence

ORD record
ord-e7b58e3f191f4e1ba42c8d638753a97f
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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