4-Methoxybenzenethiol → HCID 22132769, compound

HRID 1857114Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([SH:24])=[CH:20][CH:19]=1>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[S:24][C:21]1[CH:22]=[CH:23][C:18]([O:17][CH3:16])=[CH:19][CH:20]=1

Participants

Reactant 2

HCID 127654-Methoxybenzenethiol

HCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 22132769HCID 22132769, compoundYield 109.3%

Conditions

Temperature: 150 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (50 mg) and commercially available 4-methoxybenzenethiol (63 mg) were mixed and stirred at 150° C. for 5 minutes. Purification was carried out in the same manner as described in Example 18, and further crystallization with chloroform gave 80 mg of the title compound (yield: 100%).

Workup

customPurification
customas described in Example 18, and further crystallization with chloroform

Sources & evidence

ORD record: ord-c18294d86b614146a6f0d0905ad0565e
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06143764

Reaction notes

Loading…