(4-tert-Butylphenyl)(4-hydroxyphenyl)methanone → HCID 9932979, compound

HRID 1857121Notes

Reaction equation

HRID 1857121 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:27][CH:26]=2)=[O:24])=[CH:19][CH:18]=1>>[C:31]([C:28]1[CH:29]=[CH:30][C:25]([C:23]([C:20]2[CH:21]=[CH:22][C:17]([O:16][C:2]3[C:11]4[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=4)[N:5]=[CH:4][CH:3]=3)=[CH:18][CH:19]=2)=[O:24])=[CH:26][CH:27]=1)([CH3:34])([CH3:32])[CH3:33]

Participants

3

Reactant 2

HCID 108659(4-tert-Butylphenyl)(4-hydroxyphenyl)methanoneHCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 9932979HCID 9932979, compoundYield 11%

Conditions

Temperature
150 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (341 mg) and 4-t-butylphenyl 4-hydroxyphenyl ketone (775 mg) obtained in Example 30 were mixed and stirred at 150° C. for 15 minutes. The reaction mixture was then purified by column chromatography on silica gel eluting with hexane/acetone to obtain 72 mg of the title compound (yield: 11%).

Workup

  1. customThe reaction mixture was then purified by column chromatography on silica gel eluting with hexane/acetone

Sources & evidence

ORD record
ord-1712283d17b74cf6a2b4cb6beaf76686
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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