(4-methoxyphenyl)(naphthalen-2-yl)methanone → HCID 15640646, compound

HRID 1857123Notes

Reaction equation

HRID 1857123 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([C:13]1[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=1)=[O:12].C[S-].[Na+]>CN(C)C=O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([C:13]1[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=1)=[O:12]

Participants

4

Reactant 2

HCID 267822(4-methoxyphenyl)(naphthalen-2-yl)methanoneHCID 4378561Sodium methanethiolate

Product 1

HCID 15640646HCID 15640646, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Methoxyphenyl 2-naphthyl ketone (735 mg) obtained in Example 35 was dissolved in N,N-dimethylformamide (20 ml), sodium thiomethoxide (491 mg) was added, and the admixture was refluxed under argon for 5 hours. The reaction mixture was treated in the same manner as described in Example 33 to obtain 595 mg of the title compound (yield: 86%).

Workup

  1. temperaturethe admixture was refluxed under argon for 5 hours
  2. additionThe reaction mixture was treated in the same manner

Sources & evidence

ORD record
ord-0b6e6f7945f146d7a0d08b4d122512c5
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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