4-Chloro-6,7-dimethoxyquinoline → HCID 22132807, compound

HRID 1857127Notes

Reaction equation

HRID 1857127 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:21]([C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)=[O:22]>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:29][C:26]1[CH:27]=[CH:28][C:23]([C:21]([C:17]2[S:16][CH:20]=[CH:19][CH:18]=2)=[O:22])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 4596104-Chloro-6,7-dimethoxyquinolineHCID 130205054-(Thiophene-2-carbonyl)phenol

Product 1

HCID 22132807HCID 22132807, compoundYield 17.4%

Conditions

Temperature
160 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (112 mg) and 4-hydroxyphenyl 2-thienyl ketone (102 mg) obtained in Example 39 were mixed and stirred at 160° C. for 40 minutes. The reaction mixture was purified in the same manner as described in Example 24 to obtain 34 mg of the title compound (yield: 17%).

Workup

  1. customThe reaction mixture was purified in the same manner

Sources & evidence

ORD record
ord-1d4d0d7b37634b689bee05cfc17604ae
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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