4-Hydroxy-4'-chlorobenzophenone → HCID 22132804, compound

HRID 1857128Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)=[O:24])=[CH:19][CH:18]=1>>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([C:23]([C:20]2[CH:21]=[CH:22][C:17]([O:16][C:2]3[C:11]4[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=4)[N:5]=[CH:4][CH:3]=3)=[CH:18][CH:19]=2)=[O:24])=[CH:26][CH:27]=1

Participants

Reactant 2

HCID 1235044-Hydroxy-4'-chlorobenzophenone

HCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 22132804HCID 22132804, compoundYield 12.4%

Conditions

Temperature: 180 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (112 mg) and commercially available 4-chlorophenyl 4-hydroxyphenyl ketone (349 mg) were mixed and stirred at 180° C. for 20 minutes. The reaction mixture was purified by thin layer chromatography on silica gel eluting with chloroform/ethyl acetate (5/1) to obtain 26 mg of the title compound (yield: 12%).

Workup

customThe reaction mixture was purified by thin layer chromatography on silica gel eluting with chloroform/ethyl acetate (5/1)

Sources & evidence

ORD record: ord-3e86ef713c2749bebb6541e063cb936e
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06143764

Reaction notes

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