Anisole → 4'-Methoxy-3-(trifluoromethyl)benzophenone

HRID 1857206Notes

Reaction equation

[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14](Cl)=[O:15].FC(F)(F)S([O-])(=O)=O.[Yb+3].FC(F)(F)S([O-])(=O)=O.FC(F)(F)S([O-])(=O)=O>[N+](C)([O-])=O>[CH3:8][O:7][C:1]1[CH:6]=[CH:5][C:4]([C:14]([C:13]2[CH:17]=[CH:18][CH:19]=[C:11]([C:10]([F:9])([F:20])[F:21])[CH:12]=2)=[O:15])=[CH:3][CH:2]=1

Participants

Conditions

Temperature: 60 °C

Procedure

To commercially available nitromethane (10 ml) were added commercially available anisole (1.081 g), commercially available 3-(trifluoromethyl)benzoyl chloride (2.086 g) and commercially available ytterbium(III) trifluoromethanesulfonate (620 mg), and the admixture was stirred at 60° C. overnight. The reaction mixture was treated in the same manner as described in Example 120 to obtain 719 mg of the title compound (yield: 26%).

Workup

additionThe reaction mixture was treated in the same manner

Sources & evidence

ORD record: ord-5f0f7052a9684675bee2b717837415b3
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06143764

Reaction notes

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