反应详情

温度

160 °C

Under argon, 4-cyclohexylcarbonyl-1-hydroxybenzene (273 mg) obtained in Example 142 and 4-chloro-6,7-dimethoxyquinoline (100 mg) were dissolved in diethylene glycol dimethyl ether (0.2 ml), and the solution was refluxed at 160° C. for 30 minutes. The reaction mixture was partitioned between saturated aqueous sodium hydrogen carbonate and chloroform, and the chloroform layer was washed with brine and then dried with anhydrous magnesium sulfate. After removing the solvent by reduced-pressure distillation, the resulting residue was purified by chromatography on silica gel eluting with hexane/acetone and then with chloroform/methanol to obtain 58 mg of the title compound (yield: 33%).

1. customThe reaction mixture was partitioned between saturated aqueous sodium hydrogen carbonate and chloroform
2. washthe chloroform layer was washed with brine
3. dry with materialdried with anhydrous magnesium sulfate
4. customAfter removing the solvent
5. distillationby reduced-pressure distillation
6. customthe resulting residue was purified by chromatography on silica gel eluting with hexane/acetone