反应详情

温度

60 °C

To commercially available nitromethane (10 ml) were added commercially available anisole (1.081 g), commercially available 2-(trifluoromethyl)benzoyl chloride (2.086 g) and commercially available ytterbium(III) trifluoromethanesulfonate (620 mg), and the admixture was stirred at 60° C. for 6 hours. The reaction mixture was partitioned between water and chloroform, abd the chloroform layer was then dried with anhydrous magnesium sulfate. After removing the solvent by reduced-pressure distillation, the resulting residue was purified by chromatography on silica gel eluting with hexane/ethyl acetate to obtain 1.402 g of the title compound (yield: 50%).

1. customThe reaction mixture was partitioned between water and chloroform, abd the chloroform layer
2. dry with materialwas then dried with anhydrous magnesium sulfate
3. customAfter removing the solvent
4. distillationby reduced-pressure distillation
5. customthe resulting residue was purified by chromatography on silica gel eluting with hexane/ethyl acetate