反应详情

温度

50 °C

Commercially available 4-bromophenylacetonitrile (4.3 g) was dissolved in toluene (10 ml) and the temperature was lowered to 0° C., after which sodium hydride (1.0 g) was added, the temperature was raised to 50° C., and the admixture was then stirred for 1 hour. Next, 6,7-dimethoxy-4-chloroquinoline (2.2 g) was added, and the admixture was stirred for 15 hours, after which water was poured and the mixture was extracted with ethyl acetate. After drying with anhydrous sodium sulfate and removing the solvent by distillation, the resulting residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate (2/1) to obtain 850 mg of the title compound (yield: 22%).

1. customwas lowered to 0° C.
2. stirringthe admixture was stirred for 15 hours
3. extractionthe mixture was extracted with ethyl acetate
4. dry with materialAfter drying with anhydrous sodium sulfate
5. customremoving the solvent
6. distillationby distillation
7. customthe resulting residue was purified by column chromatography on silica gel eluting with hexane/ethyl acetate (2/1)