Benzene → HCID 22129431, compound

HRID 1857323Notes

Reaction equation

HRID 1857323 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[C:7]([CH3:19])=[C:8]([CH:12]=[CH:13][C:14]=2[S:15]([CH3:18])(=[O:17])=[O:16])[C:9](O)=[O:10])=[N:2]1.C1C=CC=CC=1.S(Cl)([Cl:28])=O>C(N(CC)CC)C>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[C:7]([CH3:19])=[C:8]([CH:12]=[CH:13][C:14]=2[S:15]([CH3:18])(=[O:17])=[O:16])[C:9]([Cl:28])=[O:10])=[N:2]1

Participants

5

Reactant 3

HCID 241BenzeneHCID 24386Thionyl ChlorideHCID 221294303-(Isoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid

Product 1

HCID 22129431HCID 22129431, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To 0.55 g of 3-(isoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid were added 10 ml of benzene, then 0.17 ml of thionyl chloride and a drop of triethylamine to heat at reflux for 2 hours. The reaction solution was cooled down. The solvent was distilled out under reduced pressure to give 3-(isoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoyl chloride.

Workup

  1. temperatureat reflux for 2 hours
  2. temperatureThe reaction solution was cooled down
  3. distillationThe solvent was distilled out under reduced pressure

Sources & evidence

ORD record
ord-b1030ab30f9d44afa1bb49b097ab270c
Source dataset
uspto-grants-2000_11
Patent number
US06147031

Reaction notes

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