Triethylamine → HCID 53657430, compound

HRID 1857464Notes

Reaction equation

HRID 1857464 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([NH:13][C:14](=[N:22][C:23]#[N:24])OC2C=CC=CC=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.C(N(CC)CC)C.[Cl:34][C:35]1[CH:42]=[CH:41][CH:40]=[CH:39][C:36]=1[CH2:37][NH2:38]>>[C:23]([NH:22][C:14]([NH:13][C:5]1[CH:6]=[C:7]([C:9]([F:11])([F:10])[F:12])[CH:8]=[C:3]([C:2]([F:26])([F:1])[F:25])[CH:4]=1)=[N:38][CH2:37][C:36]1[CH:39]=[CH:40][CH:41]=[CH:42][C:35]=1[Cl:34])#[N:24]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 666482-ChlorobenzylamineHCID 178512266HCID 178512266, compound

Product 1

HCID 53657430HCID 53657430, compoundYield 72%

Procedure

By following a procedure analogous to the one described above in Example 1b, N-(3,5-bis(trifluoromethyl)phenyl)-N'-cyano-O-phenylisourea (0.300 g, 0.8 mmol) was treated with triethylamine (0.123 ml, 0.88 mmol) and 2-chlorobenzylamine (0.107 ml, 0.88 mmol) to give the title compound as a syrup. Yield 72% (0.234 g).

Sources & evidence

ORD record
ord-696c83acdc114f01be9e27ddfeb07148
Source dataset
uspto-grants-2000_11
Patent number
US06147098

Reaction notes

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