Hydrochloric Acid → N-(4-fluorophenyl)-N'-2-butanesulfonylurea

HRID 1857575Notes

Reaction equation

HRID 1857575 reaction equation
[CH3:1][CH:2]([S:5]([NH2:8])(=[O:7])=[O:6])[CH2:3][CH3:4].C[O-].[Na+].[F:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[O:21])=[CH:15][CH:14]=1.Cl>CO>[F:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:8][S:5]([CH:2]([CH2:3][CH3:4])[CH3:1])(=[O:7])=[O:6])=[O:21])=[CH:15][CH:14]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 709554-Fluorophenyl isocyanateHCID 10942334Sodium MethoxideHCID 20482438Butane-2-sulfonamide

Product 1

HCID 22131305N-(4-fluorophenyl)-N'-2-butanesulfonylurea

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The general method of procedure B was followed with 2-butanesulfonamide (6.85 g), sodium methoxide (2.7 g), methanol (250 ml), and 4-fluorophenyl isocyanate (6.8 g) except 1N HCl was added to provide the free urea. The solid was recrystallized from benzene to provide 5.2 g of white powder with a melting point of 136-138° C.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-18ccd7195a9e4295aa05e2902a86d254
Source dataset
uspto-grants-2000_11
Patent number
US06147115

Reaction notes

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