Hydrochloric Acid → HCID 15484975, compound

HRID 1857581Notes

Reaction equation

HRID 1857581 reaction equation
[CH:1]1([S:6]([NH2:9])(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.C[O-].[Na+].[F:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1.Cl>O.O1CCCC1.CO>[F:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:9][S:6]([CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:8])=[O:7])=[O:22])=[CH:16][CH:15]=1

Participants

8

Reactant 4

HCID 313Hydrochloric AcidHCID 709554-Fluorophenyl isocyanateHCID 4645983CyclopentanesulfonamideHCID 10942334Sodium Methoxide

Product 1

HCID 15484975HCID 15484975, compoundYield 20.3%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The general method of procedure B was followed with cyclopentanesulfonamide (7.45 g), sodium methoxide (2.7 g), methanol (200 ml), tetrahydrofuran (200 ml), and 4-fluorophenyl isocyanate (6.85 g). The residue was dissolved in water and the solution acidified with 1N HCl. The resulting solid was separated and recrystallized from benzene to give 2.9 g of white solid with a melting point of 155-157° C.

Workup

  1. customThe resulting solid was separated
  2. customrecrystallized from benzene

Sources & evidence

ORD record
ord-ab55137bcce9485594811625037fe708
Source dataset
uspto-grants-2000_11
Patent number
US06147115

Reaction notes

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