Tert-Butylamine → N-tert-butylmethanesulfonamide

Temperature

0 °C

t-Butylamine (105 ml, 1.0 mole) was dissolved in THF (about 950 ml) and cooled to 0° C. Methanesulfonylchloride (57.2 g) was added and the solution allowed to warm to room temperature overnight. The mixture was filtered and the filtrate stripped to dryness. The resulting residue was dissolved in methylene chloride and washed with 1N HCl followed by washing first with water and then with brine (water saturated with NaCl). The methylene chloride layer was dried over Na2SO4, filtered, and stripped to dryness. The resulting residue was dissolved in pentane, and the solid which crystallized was collected and dried.

1. temperatureto warm to room temperature overnight
2. filtrationThe mixture was filtered
3. dissolutionThe resulting residue was dissolved in methylene chloride
4. washwashed with 1N HCl
5. washby washing first with water
6. dry with materialThe methylene chloride layer was dried over Na2SO4
7. filtrationfiltered
8. dissolutionThe resulting residue was dissolved in pentane
9. customthe solid which crystallized
10. customwas collected
11. customdried

ORD record

ord-1b5cd7a189954bd4ad89ddf2e5b4dba6

Source dataset

uspto-grants-2000_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06147115