反应详情

In ethyl acetate was dissolved 170 mg of 5-(3,5-dichlorophenylthio)-2-hydroxymethyl-4-isopropyl-1-(o-nitrobenzyl)-1H-imidazole (103c), platinum sulfided carbon was added. After replacement with hydrogen atomosphere, catalytic hydrogenation was performed at atmospheric pressure at room temperature. After 1 hour, the mixture was filtered through Celite, and the Filtrate was distilled off under reduced pressure. To the residue, diethyl ether was added, the precipitated crystals were collected by filteration, and 77 mg of Compound I-119 was obtained (yield 49%).

1. additionwas added
2. customwas performed at atmospheric pressure at room temperature
3. filtrationthe mixture was filtered through Celite
4. distillationthe Filtrate was distilled off under reduced pressure
5. additionTo the residue, diethyl ether was added
6. customthe precipitated crystals were collected by filteration, and 77 mg of Compound
7. customwas obtained (yield 49%)