反应详情

To 5 ml of concentrated hydrochloric acid was dissolved 1.3 g (2.34 mmol) of the benzyl compound (125a), the mixture was refluxed with heating for 4 hours and worked up. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract was washed with water and dried, distilled off, the residual oil was treated with ether, arid crystallized to give 5-(3,5-dichlorophenylthio)-2-(2-hydroxyethyl)-4-isopropyl-1-p-nitrobenzyl-1H-imidazole (126a). m.p. 169-171° C.

1. temperaturethe mixture was refluxed
2. temperaturewith heating for 4 hours
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water
5. customdried
6. distillationdistilled off
7. additionthe residual oil was treated with ether, arid
8. customcrystallized