Piperidine → HCID 178517788, compound

HRID 1857954Notes

Reaction equation

HRID 1857954 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:16])=[N:7][C:8]([C:12]([F:15])([F:14])[F:13])=[N:9]2)=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[N:17]1([C:2]2[CH:11]=[C:10]3[C:5]([C:6]([OH:16])=[N:7][C:8]([C:12]([F:15])([F:14])[F:13])=[N:9]3)=[CH:4][CH:3]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 178517787HCID 178517787, compound

Product 1

HCID 178517788HCID 178517788, compound

Procedure

The title compound was prepared from 7-chloro-4-hydroxy-2-trifluoromethylquinazoline (2.0 g, 8.0 mmol), as described in Example 43 (but using piperidine in place of N,N-dimethylamine) to provide the desired compound in a 96% (2.5 g) yield; m.p. 268-271° C.

Sources & evidence

ORD record
ord-60143bc82bbb44519f22f31dc314f317
Source dataset
uspto-grants-2000_11
Patent number
US06150372

Reaction notes

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