HRID1858102

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7852

Propylamine

C3H9N

HCID73277

Chloropyrazine

C4H3ClN2

结构：C#Cc1cc2c(OCCC3CCCCN3C(=O)OC(C)(C)C)c(-c3cc(C)cc(C)c3)c(=O)[nH]c2cc1Cl

HCID54433382

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C)cc(-c2c(OCCC3CCCCN3C(=O)OC(C)(C)C)c3cc(C#Cc4cnccn4)c(Cl)cc3[nH]c2=O)c1

HCID53822049

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

溶剂HCID3283

Diethyl Ether

C4H10O

CONDITIONS

反应条件

温度: 90 °C

PROCEDURE

实验过程

To a solution of 2-{2-[7-chloro-3-(3,5-dimethylphenyl)-6-ethynyl-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester (123 mg in 1.5 mL N,N-dimethylformamide) was added tetrakis(triphenylphosphine)palladium (13 mg) followed by copper(I) iodide (22 mg), n-propylamine (0.19 mL) and chloropyrazine (0.026 mL) and the mixture heated to 90° C. on an oil bath. After 10 minutes, the mixture was cooled to room temperature, diluted with diethyl ether and washed successively with water and brine then dried over magnesium sulfate. Purification of the concentrate by flash chromatography on silica gel (ethyl acetate:hexane, 30:70; then 40:60; then 50:50) gave the title compound (69 mg).

WORKUP

后处理

temperaturethe mixture was cooled to room temperature
washwashed successively with water and brine
dry with materialthen dried over magnesium sulfate
customPurification of the
concentrationconcentrate by flash chromatography on silica gel (ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8e675d90508142e18e78202e840c1a23
来源数据集: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06150352
来源说明: uspto-grants-2000_11

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][CH2:15][O:16][C:17]1[C:26]2[C:21](=[CH:22][C:23]([Cl:29])=[C:24]([C:27]#[CH:28])[CH:25]=2)[NH:20][C:19](=[O:30])[C:18]=1[C:31]1[CH:36]=[C:35]([CH3:37])[CH:34]=[C:33]([CH3:38])[CH:32]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N)CC.Cl[C:44]1[CH:49]=[N:48][CH:47]=[CH:46][N:45]=1>C(OCC)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cu]I>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][CH2:15][O:16][C:17]1[C:26]2[C:21](=[CH:22][C:23]([Cl:29])=[C:24]([C:27]#[C:28][C:44]3[CH:49]=[N:48][CH:47]=[CH:46][N:45]=3)[CH:25]=2)[NH:20][C:19](=[O:30])[C:18]=1[C:31]1[CH:36]=[C:35]([CH3:37])[CH:34]=[C:33]([CH3:38])[CH:32]=1)=[O:7])([CH3:3])([CH3:2])[CH3:4]