Methane → HCID 15385774, compound

HRID 1858349Notes

Reaction equation

HRID 1858349 reaction equation
[O:1]1[C@@H:13]2[C@@:14]34[CH2:16][CH2:17][N:18]([CH3:19])[C@@H:8]([C@@H:9]3[CH:10]=[CH:11][C@@H:12]2[O:20][C:21](=[O:30])[CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])[CH2:7][C:6]2=[C:15]4[C:2]1=[C:3]([O:31][CH2:32][O:33][CH3:34])[CH:4]=[CH:5]2.C>CO.[Pd]>[O:1]1[C@@H:13]2[C@@:14]34[CH2:16][CH2:17][N:18]([CH3:19])[C@@H:8]([C@@H:9]3[CH2:10][CH2:11][C@@H:12]2[O:20][C:21](=[O:30])[CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])[CH2:7][C:6]2=[C:15]4[C:2]1=[C:3]([O:31][CH2:32][O:33][CH3:34])[CH:4]=[CH:5]2

Participants

5

Reactant 2

HCID 297MethaneHCID 15385773HCID 15385773, compound

Product 1

HCID 15385774HCID 15385774, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4,5α-epoxy-6α-((5-methoxycarbonyl-valeryl)-oxy)-3-methoxymethoxy-17-methyl-morphinan-7-ene (0.48 g, 1.02 mmol) was dissolved in MeOH (30 ml), mixed with 10% Pd on 0.35 g of activated charcoal and then agitated for 2 hours at ambient temperature under H2 (1 bar over pressure). The catalyst was illuminated by filtering through a filter compound and the filtrate was concentrated by rotary evaporation.

Workup

  1. customThe catalyst was illuminated
  2. filtrationby filtering through a filter compound
  3. concentrationthe filtrate was concentrated by rotary evaporation

Sources & evidence

ORD record
ord-6c3966dc027548d1bb2789e41172c9c9
Source dataset
uspto-grants-2000_11
Patent number
US06150524

Reaction notes

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