Hydrochloric Acid → HCID 178513775, compound

HRID 1858507Notes

Reaction equation

HRID 1858507 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([SH:11])[S:9][CH:10]=1)=O)C.[Cl-].[NH4+:13].[Cl-].[Na+].Cl>N.O1CCCC1>[C:4]([C:6]1[N:7]=[C:8]([SH:11])[S:9][CH:10]=1)(=[O:3])[NH2:13]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 25517Ammonium ChlorideHCID 178470113HCID 178470113, compound

Product 1

HCID 178513775HCID 178513775, compoundYield 556.4%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of 4-ethoxycarbonyl-2-mercaptothiazole (150 mg) in ammonia solution (25%) (0.8 ml) was added ammonium chloride (4.2 mg) at room temperature. After stirring at the same temperature for 8 hours, the solution was poured into a mixture of tetrahydrofuran and saturated sodium chloride solution, and adjusted to pH 3.0 with 1N-hydrochloric acid. The separated tetrahydrofuran solution was washed with saturated sodium chloride solution, dried over magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (eluent: chloroform/methanol) to give 4-carbamoyl-2-mercaptothiazole (70 mg).

Workup

  1. washThe separated tetrahydrofuran solution was washed with saturated sodium chloride solution
  2. dry with materialdried over magnesium sulfate
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-999c1f973b794cbf9492126bb787c35e
Source dataset
uspto-grants-2000_11
Patent number
US06150351

Reaction notes

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