反应详情

To a mixture of 4-ethoxycarbonyl-2-mercaptothiazole (150 mg) in ammonia solution (25%) (0.8 ml) was added ammonium chloride (4.2 mg) at room temperature. After stirring at the same temperature for 8 hours, the solution was poured into a mixture of tetrahydrofuran and saturated sodium chloride solution, and adjusted to pH 3.0 with 1N-hydrochloric acid. The separated tetrahydrofuran solution was washed with saturated sodium chloride solution, dried over magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel (eluent: chloroform/methanol) to give 4-carbamoyl-2-mercaptothiazole (70 mg).

1. washThe separated tetrahydrofuran solution was washed with saturated sodium chloride solution
2. dry with materialdried over magnesium sulfate
3. customevaporated under reduced pressure