Chloride → Tert-butyl 4,4-difluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylate
Reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH:9]([Mg+:10])([CH3:11])[CH3:12].[Cl-:8].[F:13][C:14]1([F:30])[CH2:15][CH:16]([C:26](=[O:27])[O:28][CH3:29])[N:17]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:18]1.[n:1]1[c:2]([NH2:7])[cH:3][n:4][cH:5][cH:6]1>>[n:1]1[c:2]([NH:7][C:26]([CH:16]2[CH2:15][C:14]([F:13])([F:30])[CH2:18][N:17]2[C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:27])[cH:3][n:4][cH:5][cH:6]1Participants
6
Sources & evidence
- ORD record
- ord-3f5f5b9c058f4d439de26ce4235fbb68
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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