Potassium Carbonate → 1-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]-4-[(2-chlorophenyl)methyl]piperazine

HRID 1858942Notes

Reaction equation

HRID 1858942 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Cl.[O:10]1[C:14]2[CH:15]=[CH:16][C:17]([C:19]3[CH2:24][CH2:23][CH:22]([N:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)[CH2:21][CH:20]=3)=[CH:18][C:13]=2[O:12][CH2:11]1.C([O-])([O-])=O.[K+].[K+]>>[O:10]1[C:14]2[CH:15]=[CH:16][C:17]([C:19]3[CH2:24][CH2:23][CH:22]([N:25]4[CH2:30][CH2:29][N:28]([CH2:4][C:3]5[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=5[Cl:1])[CH2:27][CH2:26]4)[CH2:21][CH:20]=3)=[CH:18][C:13]=2[O:12][CH2:11]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 119062-Chlorobenzyl chlorideHCID 221220621-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine

Product 1

HCID 221220651-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]-4-[(2-chlorophenyl)methyl]piperazine

Procedure

The title compound was prepared from 2-chlorobenzyl-chloride (0.16 g, 1 mmole), 1-[4-(1,3-benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine (0.29 g, 1 mmole), and excess powdered K2CO3 as described in example 45 to give the product (78%, mp: 115-116° C.). Calc'd for C24H27ClN2O2 : C, 70.14%; H, 6.62%; N, 6.82%. Found: C, 70.25; H, 6.69%; N, 6.83%.

Sources & evidence

ORD record
ord-b4934d3b67474201b20d5f37cfd3c2c5
Source dataset
uspto-grants-2000_11
Patent number
US06153611

Reaction notes

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