Potassium Carbonate → 1-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]-4-[(3-methoxyphenyl)methyl]piperazine

HRID 1858944Notes

Reaction equation

HRID 1858944 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]Cl.[O:11]1[C:15]2[CH:16]=[CH:17][C:18]([C:20]3[CH2:25][CH2:24][CH:23]([N:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[CH2:22][CH:21]=3)=[CH:19][C:14]=2[O:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+]>>[O:11]1[C:15]2[CH:16]=[CH:17][C:18]([C:20]3[CH2:25][CH2:24][CH:23]([N:26]4[CH2:31][CH2:30][N:29]([CH2:6][C:5]5[CH:8]=[CH:9][CH:10]=[C:3]([O:2][CH3:1])[CH:4]=5)[CH2:28][CH2:27]4)[CH2:22][CH:21]=3)=[CH:19][C:14]=2[O:13][CH2:12]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 699943-Methoxybenzyl chlorideHCID 221220621-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine

Product 1

HCID 221220611-[4-(1,3-Benzodioxol-5-yl)-3-cyclohexen-1-yl]-4-[(3-methoxyphenyl)methyl]piperazine

Procedure

The title compound was prepared from 3-methoxybenzyl chloride (0.13 g, 0.8 mmole), 1-[4-(1,3-benzodioxol-5-yl)-3-cyclohexen-1-yl]piperazine (0.23 g, 0.8 mmole), and excess powdered K2CO3 as described in example 45 to give the product (45%, mp: 124-124.5° C.). Calc'd for C25H30N2O3 : C, 73.86%; H, 7.44%; N, 6.89%. Found: C, 73.88; H, 7.43%; N, 6.91%.

Sources & evidence

ORD record
ord-3dc4632c3cd040a6bc51d4592eb299a3
Source dataset
uspto-grants-2000_11
Patent number
US06153611

Reaction notes

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