1-(2-Methoxyphenyl)piperazine → HCID 22115541, compound

HRID 1858992Notes

Reaction equation

HRID 1858992 reaction equation
[C:1]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[S:8][C:7]=1[NH:17][C:18]([NH:20][CH2:21][CH2:22]Cl)=[O:19])([O:3][CH2:4][CH3:5])=[O:2].[CH3:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.C(N(C(C)C)CC)(C)C>C(#N)C>[C:1]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[S:8][C:7]=1[NH:17][C:18]([NH:20][CH2:21][CH2:22][N:35]1[CH2:34][CH2:33][N:32]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[O:25][CH3:24])[CH2:37][CH2:36]1)=[O:19])([O:3][CH2:4][CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 81531DiisopropylethylamineHCID 53807128HCID 53807128, compound

Product 1

HCID 22115541HCID 22115541, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of Example 5A (462 mg, 1.37 mmol), 1-(2-methoxyphenyl)piperazine (1.7 mmol), diisopropylethylamine (0.29 mL) in acetonitrile (5 mL) was processed as in Example1B. Purification of the residue on silica gel with ethyl acetate provided 282 mg (41%) of the title compound.

Workup

  1. customPurification of the residue on silica gel with ethyl acetate

Sources & evidence

ORD record
ord-aa57e8b3441141818a8c29188361101b
Source dataset
uspto-grants-2000_11
Patent number
US06153614

Reaction notes

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