反应详情

温度

120 °C

A mixture of compound 2 (200 mg, 0.6 mmol) and potassium carbonate (248 mg, 1.8 mmol) in DMF (5 ml) was heated at 120° C. for 24 h. The contents were poured into cold water and extracted with ethyl acetate (3×20 ml). The combined organic extract was washed with water, brine and dried over sodium suphate. The solvent was removed under reduced pressure and the resulting product was purified on a column of silica gel (EtOAc/MeOH; 98:2) to give the title compound as colorless solid (80 mg, 36%).

1. extractionextracted with ethyl acetate (3×20 ml)
2. extractionThe combined organic extract
3. washwas washed with water, brine
4. dry with materialdried over sodium suphate
5. customThe solvent was removed under reduced pressure
6. customthe resulting product was purified on a column of silica gel (EtOAc/MeOH; 98:2)