Hydrochloric Acid → HCID 86756067, compound

HRID 1859052Notes

Reaction equation

HRID 1859052 reaction equation
[CH2:1]([N:8]1[CH2:12][C@:11]2(C(N)=O)[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C@@H:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:22][O:23]C(OC)N(C)C.Cl.[CH3:31][OH:32]>C(O)C>[CH2:1]([N:8]1[CH2:12][C@:11]2([C:31]([O:23][CH3:22])=[O:32])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C@@H:10]2[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 78373Dimethylformamide dimethyl acetalHCID 86756068HCID 86756068, compound

Product 1

HCID 86756067HCID 86756067, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8.10 g of the product obtained in Step B are dissolved in 90 ml of methanol. 11.6 ml of N,N-dimethylformamide dimethyl acetal are added and the mixture is left overnight, with stirring. A solution of hydrogen chloride in ethanol is then added, and evaporation to dryness is carried out. The residue is taken up in water and washed with ethyl acetate. The aqueous phase is rendered basic with sodium carbonate and then extracted with methylene chloride. After drying and evaporating, 8.1 g of expected product are obtained.

Workup

  1. customevaporation to dryness
  2. washwashed with ethyl acetate
  3. extractionextracted with methylene chloride
  4. customAfter drying
  5. customevaporating

Sources & evidence

ORD record
ord-25ed20f19ce64f1b90c15093b9a988ba
Source dataset
uspto-grants-2000_11
Patent number
US06153640

Reaction notes

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