Aluminium lithium hydride → HCID 11414429, compound

HRID 1859053Notes

Reaction equation

HRID 1859053 reaction equation
[CH2:1]([N:8]1[CH2:12][C@:11]2([C:19](OC)=[O:20])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C@@H:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>O1CCCC1>[CH2:1]([N:8]1[CH2:12][C@:11]2([CH2:19][OH:20])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C@@H:10]2[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 86756067HCID 86756067, compound

Product 1

HCID 11414429HCID 11414429, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 4 g of compound obtained in Step C in 50 ml of tetrahydrofuran is added dropwise to a suspension of 1.03 g of LiAlH4 in 15 ml of tetrahydrofuran. The mixture is left overnight at ambient temperature. After hydrolysis and filtering off the salts, evaporation to dryness is carried out to obtain 3.5 g of expected product.

Workup

  1. customAfter hydrolysis
  2. filtrationfiltering off
  3. customthe salts, evaporation to dryness

Sources & evidence

ORD record
ord-f82a6ba682ed4fa7813f29982d7a80e5
Source dataset
uspto-grants-2000_11
Patent number
US06153640

Reaction notes

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