Hydrochloric Acid → Toluene-4-thiosulfonic acid S-(4,5-diamino-2-tert-butyl-phenyl) Ester

HRID 1859566Notes

Reaction equation

HRID 1859566 reaction equation
C(OC([NH:8][C:9]1[C:14]([NH:15]C(OC(C)(C)C)=O)=[CH:13][C:12]([S:23][S:24]([C:27]2[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=2)(=[O:26])=[O:25])=[C:11]([C:34]([CH3:37])([CH3:36])[CH3:35])[CH:10]=1)=O)(C)(C)C.Cl>C(Cl)Cl>[NH2:8][C:9]1[C:14]([NH2:15])=[CH:13][C:12]([S:23][S:24]([C:27]2[CH:32]=[CH:31][C:30]([CH3:33])=[CH:29][CH:28]=2)(=[O:26])=[O:25])=[C:11]([C:34]([CH3:37])([CH3:36])[CH3:35])[CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69756247toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl)ester

Product 1

HCID 54523728Toluene-4-thiosulfonic acid S-(4,5-diamino-2-tert-butyl-phenyl) Ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared as described in Example VV-1 from toluene-4-thiosulfonic acid S-(4,5-bis-tert-butoxycarbonylamino-2-tert-butyl-phenyl) ester (prepared in Example UU-2; 15 g, 28 mmol), CH2Cl2 (100 mL), and HCl gas. MS(APCI): 351 (M+H).

Sources & evidence

ORD record
ord-4e9aecc5e52f4832b62e2bc918762bde
Source dataset
uspto-grants-2003_03
Patent number
US06528510B1

Reaction notes

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