HRID1859585

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccc(S(=O)(=O)Sc2sc3ccccc3c2C(C)(C)C)cc1

HCID12073546

未命名化合物

HCID69734665

未命名化合物

PRODUCTS

生成物

结构：CC(C)C1(CCc2ccccc2CO)CC(O)=C(Sc2sc3ccccc3c2C(C)(C)C)C(=O)O1

HCID54677010

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The title compound was prepared according to General Method 16a using 4-hydroxy-6-[2-(2-hydroxymethyl-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one (Example E-34; 0.20 g, 0.73 mmol), toluene-4-thiosulfonic acid S-(3-tert-butyl-benzo[b]thiophen-2-yl)ester (Example BB-8; 0.302 g, 0.803 mmol), potassium carbonate (0.11 g, 0.80 mmol), and DMF (2.0 mL). The product was purified via column chromatography (eluting with EtOAc) to the title compound, mp 92-94° C.

WORKUP

后处理

customThe product was purified via column chromatography (eluting with EtOAc) to the title compound, mp 92-94° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b570d0040d3a461db021e23abe7e7831
来源数据集: uspto-grants-2003_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06528510B1
来源说明: uspto-grants-2003_03

反应 SMILES

[OH:1][C:2]1[CH2:7][C:6]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH2:19][OH:20])([CH:8]([CH3:10])[CH3:9])[O:5][C:4](=[O:21])[CH:3]=1.[C:22]([C:26]1[C:27]2[CH:45]=[CH:44][CH:43]=[CH:42][C:28]=2[S:29][C:30]=1[S:31]S(C1C=CC(C)=CC=1)(=O)=O)([CH3:25])([CH3:24])[CH3:23].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:22]([C:26]1[C:27]2[CH:45]=[CH:44][CH:43]=[CH:42][C:28]=2[S:29][C:30]=1[S:31][C:3]1[C:4](=[O:21])[O:5][C:6]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH2:19][OH:20])([CH:8]([CH3:9])[CH3:10])[CH2:7][C:2]=1[OH:1])([CH3:25])([CH3:23])[CH3:24]