Methanol → HCID 5007546, compound

HRID 1859663Notes

Reaction equation

HRID 1859663 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].[Na].[CH3:21][OH:22]>ClCCl.CO>[N+:17]([C:3]1[CH:4]=[C:5]([NH:8][C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:7][C:2]=1[O:22][CH3:21])([O-:19])=[O:18]

Participants

5

Reactant 3

HCID 887MethanolHCID 3535228N-(4-fluoro-3-nitrophenyl)benzamideHCID 5360545Sodium

Product 1

HCID 5007546HCID 5007546, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared according to the procedure described for Example 10, Step A from N-(4-fluoro-3-nitrophenyl)-benzamide (5.2 g, 20 mmol) and sodium (1.3 g, 57 mmol) using methanol in place of ethanol to afford the product (3.7 g) after chromatography on silica gel in dichloromethane/methanol 99:1.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dbdec0f924e8468ea3c57b76755362e2
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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