Aniline → HCID 18626251, compound

HRID 1859676Notes

Reaction equation

HRID 1859676 reaction equation
[O:1]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11]([OH:13])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C(Cl)=O.[NH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[O:1]([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 65578Oxalyl chlorideHCID 18626122HCID 18626122, compound

Product 1

HCID 18626251HCID 18626251, compoundYield 78.3%

Procedure

Prepared according to the procedure of Example 1 using 3-phenoxy-4-methoxybenzoic acid (0.3 g, 1.2 mmol), oxalyl chloride (0.19 g, 1.5 mmol), and aniline (0.22 g, 2.4 mmol) to afford the product (0.3 g); m.p. 200-201° C. after recrystallization from ethanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-aba36ec6eb8148c1b3f7f037ce310652
Source dataset
uspto-grants-2003_03
Patent number
US06528528B2

Reaction notes

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