p-Toluenesulfonic acid monohydrate → HCID 18625717, compound

HRID 1859967Notes

Reaction equation

HRID 1859967 reaction equation
[CH:1]([C:4]1[CH:33]=[CH:32][C:7]([O:8][CH:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][O:25]C3CCCCO3)=[CH:18][CH:17]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[OH:25][CH2:24][CH2:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([CH2:15][CH:9]([O:8][C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:2])[CH3:3])=[CH:33][CH:32]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 18625713HCID 18625713, compound

Product 1

HCID 18625717HCID 18625717, compoundYield 96.4%

Procedure

In a similar manner to that described in Reference example 3(f), a reaction was carried out using ethyl 2-(4-isopropylphenoxy)-3-[4-[2-(tetrahydropyran-2-yloxy)ethoxy]phenyl]propionate (20.6 g), which is the product of Reference example 5(e), and p-toluenesulfonic acid monohydrate (7.85 g) and the reaction mixture was treated to afford the desired compound (16.2 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-ce7fa292979b411688260df4bfbcd70b
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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