p-Toluenesulfonic acid monohydrate → HCID 18625707, compound

HRID 1859982Notes

Reaction equation

HRID 1859982 reaction equation
[CH3:1][C:2]([CH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][O:18]C2CCCCO2)=[CH:11][CH:10]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[OH:18][CH2:17][CH2:16][O:15][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][C:2]([CH3:1])([CH2:25][CH2:26][CH2:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 18625866HCID 18625866, compound

Product 1

HCID 18625707HCID 18625707, compoundYield 71.1%

Procedure

In a similar manner to that described in Reference example 3(f), a reaction was carried out using ethyl 2-methyl-2-(3-phenylpropyl)-3-[4-[2-(tetrahydropyran-2-yloxy)ethoxy]phenyl]propionate (1.64 g), which is the product of Reference example 7(e), and p-toluenesulfonic acid monohydrate (0.68 g) and the reaction mixture was treated to afford the desired compound (0.95 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-80be3bda29da4b90a1b6bc2af3c14bc4
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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