p-Toluenesulfonic acid monohydrate → HCID 18625988, compound

HRID 1859996Notes

Reaction equation

HRID 1859996 reaction equation
[CH:1]([C:4]1[CH:34]=[CH:33][C:7]([O:8][C:9]([CH3:32])([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][O:25]C3CCCCO3)=[CH:18][CH:17]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH:1]([C:4]1[CH:34]=[CH:33][C:7]([O:8][C:9]([CH3:32])([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH2:23][CH2:24][OH:25])=[CH:20][CH:21]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 18625731HCID 18625731, compound

Product 1

HCID 18625988HCID 18625988, compoundYield 75.8%

Procedure

In a similar manner to that described in Reference example 3(t), a reaction was carried out using ethyl 2-(4-isopropylphenoxy)-2-methyl-3-[4-[2-(tetrahydropyran-2-yloxy)ethoxy]phenyl]propionate (1.06 g), which is the product of Reference example 9(c), and p-toluenesulfonic acid monohydrate (0.60 g) and the reaction mixture was treated to afford the desired compound (0.66 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-aff1438e42514b7e852d75bef456d839
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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