Methanesulfonyl chloride → HCID 18625741, compound

HRID 1860004Notes

Reaction equation

HRID 1860004 reaction equation
[CH2:1]([C:5]([CH3:22])([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][OH:21])=[CH:14][CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4].[CH3:23][S:24](Cl)(=[O:26])=[O:25]>C(N(CC)CC)C>[CH2:1]([C:5]([CH3:22])([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][O:21][S:24]([CH3:23])(=[O:26])=[O:25])=[CH:14][CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18625749Ethyl 2-butyl-3-[4-(2-hydroxyethoxy)phenyl]-2-methylpropionate

Product 1

HCID 18625741HCID 18625741, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a similar manner to that described in Reference example 3(g), a reaction was carried out using ethyl 2-butyl-3-[4-(2-hydroxyethoxy)phenyl]-2-methylpropionate (2.73 g), which is the product of Reference example 10(d), triethylamine (1.85 ml) and methanesulfonyl chloride (0.75 ml) and the reaction mixture was treated to afford the desired compound (3.17 g) as a syrup.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-8b7a9a21ea714a6baa3d72b27e66a08e
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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