p-Toluenesulfonic acid monohydrate → HCID 18625878, compound

HRID 1860026Notes

Reaction equation

HRID 1860026 reaction equation
[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][O:22]C2CCCCO2)=[CH:14][CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH2:1]([CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][OH:22])=[CH:14][CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 18625937HCID 18625937, compound

Product 1

HCID 18625878HCID 18625878, compoundYield 87%

Procedure

In a similar manner to that described in Reference example 3(f), a reaction was carried out using ethyl 2-butyl-3-[4-[3-(tetrahydropyran-2-yloxy)propoxy]phenyl]propionate (4.42 g) and p-toluensulfonic acid monohydrate (2.57 g) and the reaction mixture was treated to afford the desired compound (3.02 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-72e36b6cf53043de95ec3bd90e162854
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

Loading…