p-Toluenesulfonic acid monohydrate → HCID 18625829, compound

HRID 1860068Notes

Reaction equation

HRID 1860068 reaction equation
[F:1][C:2]1[CH:31]=[CH:30][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][O:23]C3CCCCO3)=[CH:16][CH:15]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[F:1][C:2]1[CH:31]=[CH:30][C:5]([O:6][CH:7]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][OH:23])=[CH:18][CH:19]=2)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 18625796HCID 18625796, compound

Product 1

HCID 18625829HCID 18625829, compoundYield 88.7%

Procedure

In a similar manner to that described in Reference example 3(f), a reaction was carried out using ethyl 2-(4-fluorophenoxy)-3-[4-[2-(tetrahydropyran-2-yloxy)ethoxy]-phenyl]propionate (3.75 g), which is the product of Reference example 37(c), and p-toluensulfonic acid monohydrate (2.15 g) and the reaction mixture was treated to afford the desired compound (2.68 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-e29cedf079e44c04abc834cac14f5352
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

Loading…