Potassium Carbonate → HCID 18626038, compound

HRID 1860078Notes

Reaction equation

HRID 1860078 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([O:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.CS(O[CH2:32][CH2:33][NH:34][C:35](=[O:41])[O:36][C:37]([CH3:40])([CH3:39])[CH3:38])(=O)=O.C(=O)([O-])[O-].[K+].[K+]>>[C:37]([O:36][C:35]([NH:34][CH2:33][CH2:32][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([O:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]([F:24])([F:25])[F:26])=[CH:18][CH:17]=2)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:7]=1)=[O:41])([CH3:40])([CH3:39])[CH3:38]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 18625758HCID 18625758, compoundHCID 22605302tert-Butyl N-(2-((methylsulfonyl)oxy)ethyl)carbamate

Product 1

HCID 18626038HCID 18626038, compoundYield 56.1%

Procedure

In a similar manner to that described in Reference example 25, a reaction was carried out using ethyl 3-(4-hydroxyphenyl)-2-(4-trifluoromethoxyphenoxy)propionate (2.93 g), t-butyl 2-methanesulfonyloxyethylcarbamate (4.73 g) and potassium carbonate (5.46 g) and the reaction mixture was treated to afford the title compound (2.28 g) as a colorless oil.

Workup

  1. additionthe reaction mixture was treated

Sources & evidence

ORD record
ord-e446d4740107464a8aee9342677ae222
Source dataset
uspto-grants-2003_03
Patent number
US06528525B1

Reaction notes

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