反应详情

温度

100 °C

To a suspension of 2-nitro-6(5H)-phenanthridinone (3.8 g, 0.0 16 mol) in DMF (200 mL) was added an ammonium chloride solution (3%, 200 mL), followed by the addition of iron powder (22 g). The reaction mixture was stirred at 100° C. for 1 hr. The residue was removed by filtration, and the filtrate was made acidic by adding dilute HCl (25%, 20 mL). A solid separated from the solution and was filtered and washed thoroughly with cold water to remove acidic impurities. The solid was then dried under vacuum, to give hydrochloride salt of 2-amino-6(5H)-phenanthridinone (3.4 g, 89%).

1. customThe residue was removed by filtration
2. additionby adding dilute HCl (25%, 20 mL)
3. customA solid separated from the solution
4. filtrationwas filtered
5. washwashed thoroughly with cold water
6. customto remove acidic impurities
7. customThe solid was then dried under vacuum