反应详情

温度

0 °C

To a stirred solution of lithium diisopropylamide (Aldrich, 100 mL, 2M solution in THF) in THF (950 mL) at −78° C. was added a suspension of 4-benzyloxypropiophenone (Lancaster, 50 g) in THF (75 mL) over one minute. After 45 minutes, ethyl bromoacetate (Aldrich, 23 mL) was added during one minute. After one hour, the mixture was allowed to warm to 0° C. over 3 hours. The reaction was quenched with saturated NH4Cl (500 mL). The organic phase was separated and concentrated in vacuo. The residue was purified by chromatography over silica gel using 10% ethyl acetate in hexane as eluant to provide the above compound as a colorless liquid.

1. waitAfter one hour
2. customThe reaction was quenched with saturated NH4Cl (500 mL)
3. customThe organic phase was separated
4. concentrationconcentrated in vacuo
5. customThe residue was purified by chromatography over silica gel using 10% ethyl acetate in hexane as eluant