Oxalyl chloride → 2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride

HRID 1860963Notes

Reaction equation

HRID 1860963 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([C:13]([CH3:18])([CH3:17])[C:14](O)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.C(Cl)(=O)C([Cl:24])=O>ClCCl.CN(C=O)C>[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[C:5]([C:13]([CH3:18])([CH3:17])[C:14]([Cl:24])=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 98359482-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoic acid

Product 1

HCID 112671412-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

15.0 g (50 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionic acid were dissolved in 127.5 ml dichloromethane in the presence of 0.75 ml DMF. 8.76 ml (2 eq.) Oxalyl chloride were added and after 4.5 hours, the solution was rotary evaporated to dryness. 9 ml Toluene were added and the resulting solution was again rotary evaporated, then dried under high vacuum yielding 16.25 g (quant.) of 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride as a yellow oil of 86% purity according to HPLC analysis.

Workup

  1. customthe solution was rotary evaporated to dryness
  2. addition9 ml Toluene were added
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-7943a53399334fc8b8b68d8519eb2776
Source dataset
uspto-grants-2003_03
Patent number
US06531597B2

Reaction notes

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