Trifluoroacetic acid → HCID 9903131, compound

HRID 1861330Notes

Reaction equation

HRID 1861330 reaction equation
C([O:5][C:6]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]([C:18]2[CH:27]=[CH:26][C:25]3[C:24](=[O:28])[CH2:23][CH2:22][C:21]([CH3:30])([CH3:29])[C:20]=3[CH:19]=2)=[O:17])=[CH:11][CH:10]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O.C(OCC)(=O)C>ClCCl>[C:6]([CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][C:16]([C:18]2[CH:27]=[CH:26][C:25]3[C:24](=[O:28])[CH2:23][CH2:22][C:21]([CH3:30])([CH3:29])[C:20]=3[CH:19]=2)=[O:17])=[CH:13][CH:14]=1)([OH:7])=[O:5]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 129717148,8-Dimethyl-5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid 4-(tert-butoxycarbonylmethyl)phenyl ester2×

Product 1

HCID 9903131HCID 9903131, compoundYield 29.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 8,8-dimethyl-5-oxo-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid 4-(tert-butoxycarbonylmethyl)phenyl ester (Compound 19, 0.11 g, 0.229 mmol) in dichloromethane (2 mL) was treated with trifluoroacetic acid (0.85 mL and stirred at ambient temperature for 2.5 h. The volatiles were distilled off in vacuo and the residue was diluted with water and extracted with ethyl acetate (×3). The combined organic phase was dried over anhydrous sodium sulfate, filtered and evaporated in vacuo to afford a solid which was subjected to flash column chromatography over silica gel (230-400 mesh) using ethyl acetate as the eluent to afford the title compound (0.024 g, 25%).

Workup

  1. distillationThe volatiles were distilled off in vacuo
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate (×3)
  4. dry with materialThe combined organic phase was dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. customevaporated in vacuo
  7. customto afford a solid which

Sources & evidence

ORD record
ord-d11f0f4613124a099ab1b91aeb1dd0c6
Source dataset
uspto-grants-2003_03
Patent number
US06531599B2

Reaction notes

Loading…